Prioritize and Select SNPs for Association Studies with Multi-Stage Designs
نویسندگان
چکیده
منابع مشابه
Prioritize and Select SNPs for Association Studies with Multi-Stage Designs
Large-scale whole genome association studies are increasingly common, due in large part to recent advances in genotyping technology. With this change in paradigm for genetic studies of complex diseases, it is vital to develop valid, powerful, and efficient statistical tools and approaches to evaluate such data. Despite a dramatic drop in genotyping costs, it is still expensive to genotype thous...
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Genome-wide association (GWA) studies require genotyping hundreds of thousands of markers on thousands of subjects, and are expensive at current genotyping costs. To conserve resources, many GWA studies are adopting a staged design in which a proportion of the available samples are genotyped on all markers in stage 1, and a proportion of these markers are genotyped on the remaining samples in s...
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We consider two-stage case-control designs for testing associations between single nucleotide polymorphisms (SNPs) and disease, in which a subsample of subjects is used to select a panel of "tagging" SNPs that will be considered in the main study. We propose a pseudolikelihood [Pepe and Flemming, 1991: JASA 86:108-113] that combines the information from both the main study and the substudy to t...
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Large-scale genome-wide association studies are increasingly common, due in large part to recent advances in genotyping technology. Despite a dramatic drop in genotyping costs, it is still too expensive to genotype thousands of individuals for hundreds of thousands single-nucleotide polymorphisms (SNPs) for large-scale whole-genome association studies for many researchers. A two-stage design ha...
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The nature of input materials is changed as long as the product reaches the consumer in many types of manufacturing processes. In designing and improving multi-stage systems, the study of the steps separately may not lead to the greatest possible improvement in the whole system, therefore the study of inputs and outputs of each stage can be effective in improving the output quality characterist...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2008
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2007.0090